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Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

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[Two cases of digitalis toxicity with reversible and severe decrease of visual acuity].

N Nagai¹, H Ohde, Y Betsuin

¹Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Nippon Ganka Gakkai Zasshi

|February 24, 2001

Summary

This summary is machine-generated.

Digitalis toxicity can cause severe vision loss, including photophobia and reduced visual acuity. Electrophysiologic tests like the 30 Hz-flicker electroretinogram (ERG) can help detect this toxicity.

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Area of Science:

Ophthalmology
Clinical Electrophysiology
Pharmacology

Background:

Digitalis toxicity can manifest with ocular symptoms such as photophobia and xanthopsia.
Two male patients presented with symptoms indicative of digitalis toxicity.

Observation:

Patients experienced significant, reversible reductions in visual acuity and developed binocular central scotomas.
Electrophysiologic testing, including 30 Hz-flicker electroretinogram (ERG), single flash ERG, photopic ERG, and scotopic ERG, was performed.

Findings:

Visual acuity improved significantly as digitalis blood levels normalized.
Reduced amplitudes in 30 Hz-flicker ERG and photopic ERG indicated photoreceptor dysfunction, with cones more affected than rods.

Implications:

The 30 Hz-flicker ERG is a practical tool for assessing digitalis toxicity, alongside electrocardiograms and digitalis blood levels.
Severe visual dysfunction in patients undergoing digitalis therapy warrants consideration of toxicity.