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Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
da Silva AJM1, P A Melo, N M Silva
1Laboratório de Química Bioorgânica (LQB), Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Brazil.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 microM) was selected for study of its pharmacological profile.