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Solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones
A Kamal1, G S Reddy, S Raghavan
1Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India. ahmedkamal@iict.ap.nic.in
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
The solid-phase synthesis of biologically important pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones using Wang resin through amide formation and reductive cyclization procedures is described. Further, N10-substituents have been introduced in the final products and these have been cleaved from the solid support in good yields.