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Nitric oxide and cellular respiration.

M Brunori1, A Giuffrè, P Sarti

  • 1Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Italy. brunori@axrma.uniromal.it

Cellular and Molecular Life Sciences : CMLS
|February 24, 2001
PubMed
Summary
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Nitric oxide (NO) reversibly inhibits cellular respiration by interacting with cytochrome c oxidase (COX). This review explores NO

Area of Science:

  • Biochemistry
  • Cellular Respiration
  • Molecular Signaling

Background:

  • Nitric oxide (NO) is a key signaling molecule in various pathophysiological processes.
  • NO has been identified as an inhibitor of cellular respiration.

Purpose of the Study:

  • To review the interactions between nitric oxide (NO) and cytochrome c oxidase (COX).
  • To summarize the effects of NO on cellular respiration and oxygen consumption.
  • To explore the potential role of COX in nitric oxide metabolism.

Main Methods:

  • Review of existing literature on NO and COX interactions.
  • Summary of experimental evidence on NO's effect on cellular respiration.
  • Analysis of studies on purified COX and its reactions with NO.

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Main Results:

  • Nitric oxide (NO) is a potent, reversible inhibitor of in vivo oxygen consumption.
  • Experimental data show direct reactions between NO and purified cytochrome c oxidase (COX).
  • Evidence suggests COX may catalyze the degradation of NO to nitrous oxide (N2O) or nitrite.

Conclusions:

  • Cytochrome c oxidase (COX) is a primary target for nitric oxide (NO) in cellular respiration.
  • NO's inhibition of COX impacts oxygen consumption.
  • COX may play a role in the in vivo catabolism of nitric oxide.