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Myosin-V: head to tail

D W Provance1, J A Mercer

  • 1McLaughlin Research Institute, Great Falls, Montana 59405, USA.

Cellular and Molecular Life Sciences : CMLS
|February 24, 2001
PubMed

Insights

Myosin-V is a crucial motor protein for organelle transport in eukaryotes. This review details myosin-V

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Myosin-V is a highly conserved motor protein superfamily.
  • It plays a vital role in intracellular transport across diverse species.
  • Multiple myosin-V family members are common in many organisms.

Purpose of the Study:

  • To review the current research on myosin-V cellular functions.
  • To elucidate the roles of myosin-V head, neck, and tail domains.

Main Methods:

  • Literature review of existing myosin-V research.
  • Analysis of studies on myosin-V structure-function relationships.

Main Results:

  • Myosin-V is fundamental for organelle transport in higher eukaryotes.
  • Cargoes include melanosomes, synaptic vesicles, vacuoles, and mRNA.
  • Domain-specific functions contribute to myosin-V's transport capabilities.

Conclusions:

  • Myosin-V is essential for fundamental cellular processes.
  • Understanding its domains is key to comprehending its function.
  • Myosin-V is a ubiquitous and vital component of eukaryotic cell biology.

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