Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulation of serotonin transporter function by interleukin-4.

R Mössner1, S Daniel, A Schmitt

  • 1Department of Psychiatry, University of Würzburg, Germany.

Life Sciences
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the LRINEC Score: A stratified diagnostic algorithm for subacute and atypical necrotizing fasciitis.

Annales de chirurgie plastique et esthetique·2026
Same author

The Absence of Claudin-10 in the Enamel Organ Alters Its Integrity.

Journal of dental research·2025
Same author

Primary central nervous system lymphoma of the spinal cord: A LOC network cohort study.

Revue neurologique·2024
Same author

CDK9 inhibition as an effective therapy for small cell lung cancer.

Cell death & disease·2024
Same author

Expanding self-consciousness of health status for diabetes chronic complications among adults: a systematic review.

European review for medical and pharmacological sciences·2024
Same author

Understanding morphological evolution and sediment dynamics at multi-time scales helps balance human activities and protect coastal ecosystems: An example with the Gironde and Pertuis Marine Park.

The Science of the total environment·2023
Same journal

RPS20 phosphorylation acts as a molecular switch to integrate inflammatory and oxidative stress signals in sepsis.

Life sciences·2026
Same journal

Local lymphatic circulation disorder: A key promoter of tissue inflammation and organ fibrosis.

Life sciences·2026
Same journal

Gestational homocysteine exposure induces preeclampsia-like phenotypes and alters fetal neurodevelopmental gene expression via impaired decidualization.

Life sciences·2026
Same journal

SLFN11 binds DDX1 to counteract human mesenchymal stem/stromal cell senescence through inhibition of mTOR/eIF4E signaling pathway activation.

Life sciences·2026
Same journal

Corrigendum to "Adipose stem cells-derived microvesicles and chicken egg-derived exosomes attenuate cardiac ischemia/reperfusion injury through AKT/ERK/Nrf2/HO-1 axis to inhibit apoptosis and inflammation and restore autophagy" [Life Sci. 395 (2026) 124364].

Life sciences·2026
Same journal

MAGED1 stabilizes NEUROD1 to promote Per3 expression in the pineal gland.

Life sciences·2026
See all related articles

Interleukin-4 (IL-4) reduces serotonin transporter (5-HTT) activity, particularly in individuals with a specific gene variant. This suggests a communication pathway between immune responses and the central nervous system.

Area of Science:

  • Neuroimmunology
  • Molecular Psychiatry

Background:

  • Serotonin (5-HT) is crucial for nervous and immune system communication.
  • The 5-HT transporter (5-HTT) regulates 5-HT signaling, and its modulation by cytokines is of growing interest.
  • Pro-inflammatory cytokines upregulate 5-HTT, but the role of anti-inflammatory cytokines is less understood.

Purpose of the Study:

  • To investigate the effect of the anti-inflammatory cytokine interleukin-4 (IL-4) on the 5-HT transporter (5-HTT).
  • To examine the influence of a 5-HTT gene promoter polymorphism (5-HTTLPR) on IL-4's effect.

Main Methods:

  • Using immortalized B lymphocytes expressing 5-HTT.
  • Assessing IL-4's impact on 5-HT uptake in cells with different 5-HTTLPR genotypes.

Main Results:

Related Experiment Videos

  • IL-4 caused a dose-dependent decrease in 5-HT uptake.
  • This reduction was more pronounced in cell lines with the high-activity, long allele of the 5-HTTLPR.

Conclusions:

  • A differential modulation of 5-HTT by pro- and anti-inflammatory cytokines is emerging.
  • This cytokine-mediated regulation may serve as a mechanism for the immune system to signal its status to the central nervous system.