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The absorption of protein hormones through rabbit rhinal mucosa
B Dolinska1, F Ryszka, A Suszka-Switekz
1Department of Applied Pharmacy and Drug Technology Silesian Medical Academy ul. Kasztanowa 3, 41-205 Sosnowiec, Poland.
Bollettino Chimico Farmaceutico
|February 24, 2001
Abstract:
The absorptions through rabbit rhinal mucosa of the following hormones with a protein-peptide structure: thyrotropin-releasing hormone, insulin, and prolactin, were compared. A very high negative correlation between the molecular weight of the hormones and the total amount of the hormones molecular weight of hormones absorbed through the rhinal mucosa (r = 0.973) was found. Within 2 hours of the experiment, 33.94% TRH, 23.96% INS, and only 11.01% PRL, were absorbed from the administered dose.