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Ventriculitis due to Cryptococcus uniguttulatus.

L H McCurdy1, J D Morrow

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA.

Southern Medical Journal
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

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This is the first reported human infection caused by Cryptococcus uniguttulatus, a rare fungal pathogen. The patient recovered after treatment with amphotericin B, indicating a potential therapeutic option for this unusual infection.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Case Reports

Background:

  • Infections caused by non-neoformans Cryptococcus species are uncommon in humans.
  • Cryptococcus uniguttulatus is a yeast typically found in environmental sources, rarely implicated in human disease.

Observation:

  • A 65-year-old female patient developed ventriculitis following surgical repair of an internal carotid artery aneurysm.
  • The causative agent was identified as Cryptococcus uniguttulatus.

Findings:

  • In vitro antifungal susceptibility testing revealed that the isolated Cryptococcus uniguttulatus strain was sensitive to amphotericin B and itraconazole.
  • Clinical resolution of ventriculitis was achieved with amphotericin B therapy.

Implications:

Related Experiment Videos

  • This case highlights Cryptococcus uniguttulatus as a potential human pathogen, expanding the spectrum of cryptococcal infections.
  • The findings suggest that amphotericin B is an effective treatment for ventriculitis caused by Cryptococcus uniguttulatus.
  • Further research is warranted to understand the epidemiology and clinical spectrum of non-neoformans Cryptococcus infections.