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Physico-chemical characterization of polysaccharide vaccines
1Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20852, USA.
Developments in Biologicals
|February 24, 2001
Abstract:
An increasing number of sophisticated analytical techniques, including NMR spectroscopy, are currently being applied to the quality control of polysaccharide and polysaccharide-based vaccines. These methodologies are providing more precise and more detailed profiles of these vaccines. NMR spectroscopy also provides a convenient and powerful technique to monitor alterations of the polysaccharide in the production of protein conjugate vaccines.