Physico-chemical characterization of polysaccharide vaccines
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Updated: Oct 9, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
1Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20852, USA.
Abstract:
An increasing number of sophisticated analytical techniques, including NMR spectroscopy, are currently being applied to the quality control of polysaccharide and polysaccharide-based vaccines. These methodologies are providing more precise and more detailed profiles of these vaccines. NMR spectroscopy also provides a convenient and powerful technique to monitor alterations of the polysaccharide in the production of protein conjugate vaccines.
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