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Related Experiment Videos

Monitoring cerebral perfusion after subarachnoid hemorrhage using CT.

D G Nabavi1, L M LeBlanc, B Baxter

  • 1Imaging Research Laboratories, John P. Robarts Research Institute, London, Ontario, Canada.

Neuroradiology
|February 24, 2001
PubMed
Summary

Dynamic CT scans measuring cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) are feasible and diagnostically relevant in the early weeks after subarachnoid hemorrhage (SAH). These measurements help identify vasospasm and related complications.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Aneurysmal subarachnoid hemorrhage (SAH) poses significant risks, including delayed cerebral ischemia due to vasospasm.
  • Early and accurate assessment of cerebral perfusion is crucial for managing SAH patients.

Purpose of the Study:

  • To evaluate the feasibility and diagnostic value of dynamic contrast-enhanced CT (DCE-CT) for measuring cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT).
  • To assess these perfusion parameters within the first three weeks post-SAH and correlate them with clinical outcomes, vasospasm, and infarcts.

Main Methods:

  • Prospective study involving 15 patients with aneurysmal SAH.
  • Performed 59 dynamic CT studies, analyzing 944 regions of interest (ROI).
  • Measured CBF, CBV, and MTT, correlating findings with clinical course, time post-event, and vasospasm presence.

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Main Results:

  • Established reference values for CBF (33.8±19.3 ml/100 g/min), CBV (3.3±1.3 ml/100 g), and MTT (7.3±3.9 s).
  • Found significant differences in CBF and CBV between grey and white matter, varying with time post-SAH.
  • Demonstrated significant differences in perfusion parameters between patients with and without significant vasospasm or vasospasm-related infarcts.

Conclusions:

  • Repetitive dynamic CT measurements of CBF, CBV, and MTT are feasible and diagnostically relevant in the early phase after SAH.
  • These perfusion parameters can help detect vasospasm and identify infarcts, aiding in patient management.