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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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End organ protection by calcium-channel blockers
1Bendheim Department of Cardiology, Jesselson Heart Center, Jerusalem, Israel.
Calcium-channel blockers (CCBs) offer significant end-organ protection, particularly for the heart and kidneys. Studies show CCBs reduce left ventricular mass and preserve kidney function, especially in diabetic patients.
Area of Science:
- Cardiology
- Pharmacology
Background:
- End-organ protection is crucial in managing cardiovascular diseases.
- Antihypertensive, anti-heart failure, and anti-ischemic medications are key therapeutic agents.
- Calcium-channel blockers (CCBs) are widely used in cardiovascular pharmacotherapy.
Purpose of the Study:
- To review the evidence on end-organ protective effects of CCBs.
- To evaluate the impact of CCBs on cardiovascular and renal health.
- To explore the potential antiatherogenic and antiplatelet properties of CCBs.
Main Methods:
- Review of existing literature on CCB effects.
- Analysis of studies involving normotensive and hypertensive patients.
- Examination of data from diabetic patients and animal models.
Main Results:
- Long-term CCB treatment reduced left ventricular mass and medial thickness.
- CCBs improved endothelial function and preserved kidney function in diabetics.
- Combination therapy with ACE inhibitors and CCBs enhanced kidney protection.
Conclusions:
- CCBs demonstrate significant end-organ protective effects, including cardiac and renal benefits.
- CCBs may offer advantages in patients with hypertension and diabetes.
- Further research is needed to confirm antiatherogenic effects in humans.
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