Related Experiment Videos
Isolated pelvic hyperthermochemotherapeutic perfusion--an experimental study on isolating efficacy.
1Department of General Surgery, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
|February 24, 2001
Summary
This study developed a hyperthermochemotherapy perfusion model to assess drug leakage. The isolated pelvic method effectively contained hyperthermia and adriamycin, showing minimal systemic side effects.
Area of Science:
- Oncology
- Pharmacology
- Vascular Surgery
Background:
- Hyperthermochemotherapy offers potential for localized cancer treatment.
- Evaluating drug and heat leakage is crucial for safety and efficacy.
- Isolated organ perfusion can enhance drug delivery and minimize systemic toxicity.
Purpose of the Study:
- To develop and evaluate an isolated pelvic perfusion model for hyperthermochemotherapy.
- To quantify the leakage of hyperthermia and adriamycin from pelvic circulation to systemic circulation.
- To assess the associated systemic side/toxic effects of this perfusion model.
Main Methods:
- Developed an isolated pelvic perfusion model using femoral artery and vein catheters.
- Administered hyperthermic (48-55°C) adriamycin (50 µg/ml) for 30 minutes.
- Monitored pelvic temperature (43±0.5°C) and adriamycin concentrations in pelvic efflux and systemic serum.
Main Results:
- Pelvic adriamycin concentrations were 12-46 times higher than systemic serum (P < 0.001).
- Increased perfusion pressure slightly increased leakage but was not statistically significant (P > 0.05).
- Systemic blood dynamics remained stable with no observed organic injuries.
Conclusions:
- Isolated pelvic hyperthermochemotherapeutic perfusion demonstrates high isolating efficacy.
- Hyperthermia and adriamycin are effectively confined to the pelvic region.
- The model exhibits minimal side effects on systemic circulation and vital organs.