Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Tests for bronchial asthma].

T Adachi1, J Chihara

  • 1Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita 010-8543.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinoic acids up-regulate functional eosinophil-driving receptor CCR3.

Allergy·2013
Same author

Increased urinary biopyrrins in patients with asthma.

Allergy·2010
Same author

Clinical evaluation after a notification policy of linezolid use: a case series of 22 patients.

Journal of chemotherapy (Florence, Italy)·2009
Same author

Soluble vascular cell adhesion molecule-1 induces human eosinophil migration.

Allergy·2009
Same author

Thioredoxin reduces C-C chemokine-induced chemotaxis of human eosinophils.

Allergy·2009
Same author

Sex-related splenocyte function in a murine model of allergic asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2008
Same journal

[The Role of Laboratory Medicine in Hematopoietic Stem Cell Transplantation "Echocardiogram"].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Significance of Pulmonary Function Testing Before and After Allogeneic Stem Cell Transplantation].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[Blood Transfusion Inspection].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Role of Clinical Laboratory Technicians at Bone Marrow Transplantation : Blood Test].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Foundation of Allogeneic Hematopoietic Stem Cell Transplantation and the Role of Clinical Laboratory Tests in This Field].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[How to Interpret Data from Routine Laboratory Tests].

Rinsho byori. The Japanese journal of clinical pathology·2019
See all related articles

Asthma patients show elevated levels of RANTES and soluble ICAM-1, indicating allergic airway inflammation. New temperature-based tests may also help evaluate asthma status.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Biomarkers

Context:

  • Allergic airway inflammation is a key feature of bronchial asthma.
  • Eosinophil activation, adhesion molecules, cytokines, and chemokines are critical in asthma pathogenesis.
  • Clinical parameters are needed to assess asthma status effectively.

Purpose:

  • To measure RANTES and soluble ICAM-1 (sICAM-1) levels in asthma patients.
  • To assess intracellular EG2 expression in eosinophils for direct activation detection.
  • To evaluate expiratory flow temperature and temperature flux as novel markers of airway inflammation.

Summary:

  • Plasma RANTES and serum/sputum sICAM-1 levels were significantly higher in asthma patients compared to healthy subjects.
  • Elevated RANTES levels correlated with asthma attacks.

Related Experiment Videos

  • Increased EG2-positive eosinophils and temperature flux coefficient were observed in asthmatic patients, suggesting inflammation.

    • Impact:

    • RANTES, sICAM-1, EG2 expression, and temperature flux show potential as clinical parameters for evaluating allergic airway inflammation in asthma.
    • These markers may aid in assessing asthma status and guiding treatment decisions.
    • Novel temperature-based measurements offer a new approach to monitor airway inflammation.