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Ankylosing rheumatoid arthritis.

R Grahame, A Calin, M Tudor

    Rheumatology and Rehabilitation
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    This study on rheumatoid arthritis patients found widespread bony ankylosis causing disability, but cervical spine ankylosis may protect the spinal cord. Absence of HLA 27 antigen helps exclude Ankylosing Spondylitis.

    Area of Science:

    • Rheumatology
    • Immunogenetics

    Background:

    • Rheumatoid arthritis is a chronic autoimmune disease.
    • Long-standing rheumatoid arthritis can lead to joint damage and disability.

    Purpose of the Study:

    • To assess the clinical, haematological, serological, radiological, and histocompatibility profiles of patients with long-standing rheumatoid arthritis.
    • To investigate the relationship between bony ankylosis, disability, and specific histocompatibility antigens.

    Main Methods:

    • Clinical evaluation of eleven in-patients with rheumatoid arthritis.
    • Haematological and serological tests, including sedimentation rate.
    • Radiological assessment of joint status.
    • Histocompatibility antigen typing (HLA 27).

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    Main Results:

    • Widespread bony ankylosis was observed in peripheral joints and the cervical spine.
    • Bony ankylosis was a primary cause of disability.
    • Absence of the histocompatibility antigen HLA 27 was noted, aiding in the exclusion of Ankylosing Spondylitis.
    • Elevated sedimentation rates indicated ongoing rheumatoid disease activity despite clinical impression.

    Conclusions:

    • Cervical spine ankylosis may offer protection to the spinal cord.
    • The absence of HLA 27 is a valuable diagnostic indicator for differentiating from Ankylosing Spondylitis.
    • Rheumatoid arthritis remains an active process even in long-standing cases with apparent inactivity.