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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 11, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Anorectal Crohn's disease.

S J McClane1, J L Rombeau

  • 1Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio, USA.

The Surgical Clinics of North America
|February 24, 2001
PubMed
Summary

Crohn's disease frequently causes anorectal conditions, ranging from mild to severe. Current treatments offer some symptom relief, but new therapies are needed for lasting improvement.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery

Background:

  • Anorectal disease is a common complication in Crohn's disease patients.
  • Manifestations range from asymptomatic skin tags to severe perineal destruction and sepsis.

Purpose of the Study:

  • To review the current understanding and management of anorectal diseases in Crohn's disease.
  • To highlight the limitations of existing treatments and the need for novel therapeutic approaches.

Main Methods:

  • Literature review of clinical manifestations, surgical, and medical management strategies.
  • Discussion of current treatment outcomes and future research directions.

Main Results:

  • Surgical management requires a conservative approach focusing on sepsis control, sphincter preservation, and symptom palliation.

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

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Last Updated: Jul 11, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

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  • Medical therapies provide partial symptom improvement but lack enduring efficacy for most perianal issues.

    • Conclusions:

    • Effective and lasting treatment for anorectal Crohn's disease remains a significant clinical challenge.
    • Ongoing research into new treatment modalities is crucial for improving patient outcomes.