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Esmolol in a case of severe tetanus. Adequate haemodynamic control achieved despite markedly elevated catecholamine
S C Beards1, J Lipman, P A Bothma
1Intensive Care Unit, Baragwanath Hospital and Department of Anaesthesia, University of Witwatersrand, Johannesburg.
Abstract:
A patient with severe tetanus, who had a sympathetic crisis while sedated with 30 mg/h diazepam and 30 mg/h morphine, is described. Satisfactory control of the haemodynamic crisis was achieved with bolus doses of esmolol to a total of 180 mg. A disturbing finding was that although there was adequate control of the tachycardia and hypertension, arterial catecholamine levels remained markedly elevated. Adrenaline levels of 531 pg/ml (normal 10-110 pg/ml) and noradrenaline levels of 1,036 pg/ml (normal 100-500 pg/ml) were recorded when the patient had a systolic arterial pressure of 110 mmHg and a heart rate of 97/min. The implications of this finding are discussed.