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Pleomorphic xanthoastrocytoma--a clinicopathological study.

C Sundaram1, M R Naidu, J J Reddy

  • 1Departments of Pathology, Radiology, Nizams Institute of Medical Sciences and Neurosurgery, Gandhi Hospital, Hyderabad.

Indian Journal of Pathology & Microbiology
|February 24, 2001
PubMed
Summary

This study presents six cases of Pleomorphic Xanthoastrocytoma, a rare brain tumor. These tumors, often found in the temporal/parietal lobes, can cause seizures and appear as space-occupying lesions on CT scans.

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Area of Science:

  • Neuro-oncology
  • Neuropathology

Background:

  • Pleomorphic Xanthoastrocytoma (PXA) is a rare glial tumor of the central nervous system.
  • Understanding its presentation and histopathological features is crucial for diagnosis and management.

Observation:

  • Six cases of PXA were analyzed, with one presenting with recurrent seizures and others as intracranial space-occupying lesions.
  • Tumors were located in the temporal/parietal lobes, exhibiting cystic and solid components with contrast enhancement on CT scans.

Findings:

  • Histopathological examination revealed characteristic pleomorphic giant cells and cells with vacuolated cytoplasm.
  • Strong positive staining for glial fibrillary acidic protein (GFAP) was observed in all cases, confirming glial origin.

Implications:

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  • These findings contribute to the understanding of PXA's clinical and radiological presentation.
  • Accurate histopathological diagnosis, supported by GFAP positivity, is essential for appropriate patient management of this rare brain tumor.