Elution of bisphenol A from composite resin: a model experiment

To understand the leaching characteristics of bisphenol A (BPA) from composite resins, we prepared experimental composite resins containing known amounts of BPA and examined the BPA elution from the resins in water and methanol at 37 degrees C. The concentration of BPA in each eluate was determined by high performance liquid chromatography. Cumulative BPA release was calculated and plotted against extraction time. The elution of BPA was rapid during a 6-hr period for both solvents, and then declined and continued steadily. Plots of square root of the amount of BPA leached against logarithm of extraction time produced good linear relationships from a 6-hr period thereafter. Extrapolation of the relationship enabled prediction of the amount of BPA to be leached in the long term. The present results suggested that little or no estrogenic effect due to long-term elution of BPA from commercial Bis-GMA-based resins is expected in practice.