Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sildenafil citrate: a therapeutic update.

E G Boyce1, E M Umland

  • 1Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Pennsylvania 19104, USA. e.boyce@usip.edu

Clinical Therapeutics
|February 24, 2001
PubMed
Summary

Sildenafil is an effective treatment for erectile dysfunction in men across various conditions. Careful consideration of risks, benefits, and patient-specific factors is crucial for its prescription.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Second-line Drugs on the Progression or Regression of Rheumatoid Nodules.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Risedronate: a new oral bisphosphonate.

Clinical therapeutics·2001
Same author

Phytoestrogens as therapeutic alternatives to traditional hormone replacement in postmenopausal women.

Pharmacotherapy·2000
Same author

The impact of estrogen replacement therapy and raloxifene on osteoporosis, cardiovascular disease, and gynecologic cancers.

The Annals of pharmacotherapy·2000
Same author

Cardiovascular effects of troglitazone.

The Annals of pharmacotherapy·1999
Same author

Potential risk factors associated with thrombocytopenia in a surgical intensive care unit.

Pharmacotherapy·1999

Area of Science:

  • Pharmacology
  • Urology
  • Cardiology

Background:

  • Sildenafil citrate, approved in 1998, is widely used for erectile dysfunction (ED).
  • Recent research has enhanced understanding of sildenafil's efficacy, safety, contraindications, and drug interactions.
  • Expanded knowledge includes its application in specific patient groups.

Purpose of the Study:

  • To review recent studies on sildenafil's efficacy and safety in treating erectile dysfunction.
  • To examine adverse effects, drug interactions, and socioeconomic factors of sildenafil use.
  • To focus on sildenafil's effectiveness in specific patient populations, including those with prostate cancer, diabetes, heart disease, spinal cord injuries, and neurologic disorders.

Main Methods:

  • Searched MEDLINE, PREMEDLINE, and International Pharmaceutical Abstracts for literature from January 1999 to August 2000.
  • Included clinical studies, case reports, commentaries, and editorials on sildenafil, Viagra, and erectile dysfunction.
  • Focused on identifying efficacy, safety, and interaction data.

Main Results:

  • Sildenafil is effective for ED in men with conditions like diabetes, neurologic disorders, and post-prostatectomy/radiation.
  • It shows limited efficacy in women, except for SSRI-associated sexual dysfunction.
  • Sildenafil has an acceptable safety profile, but risks exist for patients with cardiovascular disease or those on nitrates. Drug interactions with CYP3A4 inhibitors can increase toxicity.

Conclusions:

  • Sildenafil is a highly effective first-line therapy for male erectile dysfunction.
  • Prescribing decisions should weigh cost-benefit, patient access, and insurance coverage.
  • Further research and clinical judgment are essential for optimal patient management.

Related Experiment Videos