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Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia
S A Fadilah1, I Faridah, S K Cheong
1Department of Haematology and Transplantation, MAKNA-HUKM Cancer Institute, Hospital Universiti Kebangsaan Malaysia, Jalan Tenteram, Cheras, 56000 Kuala Lumpur.
The Medical Journal of Malaysia
|February 28, 2001
Abstract:
The effect of L-asparaginase on the thyroid gland has not been well documented. We report the first two cases of hyperthyroidism associated with thyroid nodule following L-asparaginase therapy for acute lymphoblastic leukemia (ALL). The thyroid function abnormalities were not severe, short-lived and did not require specific therapy.