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Interaction profile and tolerability of barnidipine
H J Beudeker1, J W van der Velden, E M van der Aar
1Yamanouchi Europe B.V, Leiderdorp, The Netherlands.
International Journal of Clinical Practice. Supplement
|February 28, 2001
Summary
Barnidipine, a single S-S optical isomer calcium antagonist, shows mild adverse events and comparable safety in elderly patients. Its favorable pharmacokinetic interactions are unaffected by food and unlikely to be clinically relevant with alcohol or grapefruit juice.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Barnidipine is a novel dihydropyridine calcium antagonist available as a single S-S optical isomer.
- Investigating enantiomer-specific properties is crucial due to known differences in kinetics, dynamics, and safety compared to racemic calcium antagonists.
Purpose of the Study:
- To review the safety and interaction profile of barnidipine.
- To assess its tolerability across different age groups, including the elderly.
Main Methods:
- Review of clinical data on barnidipine's safety and pharmacokinetic interactions.
- Analysis of adverse event profiles and drug-drug interaction studies.
Main Results:
- Adverse events are typically mild to moderate, occurring early in treatment.
- Safety in elderly patients is comparable to the general population, allowing use without dose adjustment.
- Barnidipine exhibits a favorable pharmacokinetic interaction profile, with minimal impact from food, alcohol, or grapefruit juice.
Conclusions:
- Barnidipine demonstrates a well-established interaction and tolerability profile across all age groups.
- Its safety and predictable interactions support its use in managing hypertension.