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Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD
J Volkmann1, N Allert, J Voges
1Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany. volkmann@neurologie.uni-duesseldorf.de
Neurology
|February 27, 2001
Abstract:
The authors retrospectively compared 1-year results of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN; n = 16) and internal pallidum (GPi) (n = 11) in advanced PD and found about equal improvements in "off" period motor symptoms, dyskinesias, and fluctuations. STN stimulation reduced medication requirements by 65% and required significantly less electrical power. These advantages contrasted with a need for more intensive postoperative monitoring and a higher incidence of adverse events related to levodopa withdrawal.