Related Experiment Video
Updated: Jul 31, 2026
Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
Published on: January 20, 2012
Neurophysiological mechanisms underlying motor evoked potentials in anesthetized humans. Part 2. Relationship between
V Deletis1, Z Rodi, V E Amassian
1Institute for Neurology and Neurosurgery, Beth Israel Medical Center - Singer Division, 170 East End Avenue, Rm. 311, New York, NY 10128, USA. vdeletis@bethisraelny.org
Objective And Methods:
Direct (D) and transynaptic, (i.e. indirect) (I) corticospinal tract (CT) discharges were simultaneously recorded epidurally with muscle motor evoked potentials (MEPs) in patients under different levels of anesthesia. The effects of the one, two or more equal electrical stimuli, applied transcranially or directly to the motor cortex, were studied at different interstimulus intervals (ISIs) to determine the optimal conditions for eliciting I and MEP responses.
Results And Conclusion:
At anesthetic levels permiting large D and I responses to single stimuli, optimal D and I wave facilitation and MEPs occurred with two stimuli at ISIs greater than 4 ms (e.g. at 5.9 and 8 ms). When single electrical stimuli elicit only a D response, optimal MEP responses are determined by the number of stimuli and the recovery of CT fibers excitability (e.g. at an ISI of 4 ms).
