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Updated: Sep 27, 2026
A Protocol for Transcranial Photobiomodulation Therapy in Mice
Published on: November 18, 2018
The Role of Photobiomodulation Therapy in Enhancing Neurogenesis: Mechanisms and Applications
Wenhao Wang1, Qianting Deng1, Timon Cheng-Yi Liu1
1School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Background:
Adult neurogenesis, critical for neural repair and functional plasticity, is impaired in neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and traumatic brain injury (TBI).
Objective:
This review summarizes the physiological basis of adult neurogenesis and photobiomodulation (PBM) fundamentals, clarifies PBM-induced neurogenesis mechanisms, evaluates its pre-clinical/clinical efficacy and safety, and addresses translational challenges to support clinical translation.
Materials And Methods:
We synthesized relevant literature, covering adult neurogenesis characteristics, PBM principles/mechanisms, pre-clinical studies in disorder models, clinical safety/efficacy data, and comparisons with conventional neurogenic therapies.
Conclusions:
PBM promotes neurogenesis via regulating neural stem cell activity, mitochondrial function, and oxidative stress. Pre-clinical/clinical evidence confirms its safety and efficacy; despite parameter and long-term safety challenges, it has great potential in neuroregenerative medicine.
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