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Simultaneous Electrophysiological Recording and Calcium Imaging of Suprachiasmatic Nucleus Neurons
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Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

G E Hardingham1, F J Arnold, H Bading

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, England.

Nature Neuroscience
|February 27, 2001
PubMed
Summary

Nuclear calcium signals, not cytoplasmic protein import, activate CREB-mediated transcription for memory storage in neurons. This finding reveals a novel pathway for information processing in the brain.

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