Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intestinal metal ion absorption: an update.

Andreas Rolfs1, Matthias A. Hediger

  • 1Membrane Biology Program, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Current Opinion in Gastroenterology
|February 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.

Cell reports·2014
Same author

Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community.

Nucleic acids research·2009
Same author

High-resolution DNA-binding specificity analysis of yeast transcription factors.

Genome research·2009
Same author

Next-generation high-density self-assembling functional protein arrays.

Nature methods·2008
Same author

Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae.

Proceedings of the National Academy of Sciences of the United States of America·2008
Same author

A biomedically enriched collection of 7000 human ORF clones.

PloS one·2008

This review details key proteins for intestinal iron, zinc, and copper absorption. Understanding these metal ion transporters is crucial for normal health and disease states.

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Biochemistry

Background:

  • Intestinal metal ion absorption is vital for health.
  • Dysregulation of metal ion transport is linked to various pathologies.
  • Key proteins involved in iron, zinc, and copper transport are being identified.

Purpose of the Study:

  • To review the primary proteins responsible for intestinal absorption of iron, zinc, and copper.
  • To highlight recent advancements in understanding metal ion transport mechanisms.
  • To discuss the significance of identified transporters in physiological and pathological contexts.

Main Methods:

  • Literature review focusing on metal ion transport proteins.
  • Identification of apical and basolateral transporter complexes for iron.

Related Experiment Videos

  • Homology-based identification of novel zinc and copper transporters.

    • Main Results:

    • The apical iron transporter DCT1 has been described.
    • The basolateral iron transport complex includes IREG1/MTP1 and hephaestin.
    • Novel zinc and copper transporters have been identified through homology to yeast and plant counterparts.

    Conclusions:

    • The identified transporters are essential for maintaining cellular homeostasis of iron, zinc, and copper.
    • The variety of identified transporters underscores the critical roles of these metals in numerous biological processes.
    • Further research into these transporters will advance understanding of metal ion-related diseases.