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Chronic mucocutaneous candidiasis
1Department of Medicine, University of Colorado Health Sciences Center, Denver 80206-1210, USA. ckirkpatrick@eri.uchsc.edu
The Pediatric Infectious Disease Journal
|February 27, 2001
Summary
Chronic mucocutaneous candidiasis presents as a spectrum of persistent fungal infections. Genetic factors and impaired T lymphocyte cytokine production contribute, but antifungal drugs and immunotherapy offer effective treatment options.
Area of Science:
- Immunology
- Dermatology
- Infectious Diseases
Background:
- Chronic mucocutaneous candidiasis (CMC) is a group of disorders characterized by persistent or recurrent Candida infections.
- These conditions affect the skin, nails, and mucous membranes.
- Genetic predispositions and immune system defects are implicated in CMC.
Purpose of the Study:
- To define chronic mucocutaneous candidiasis as a spectrum of disorders.
- To identify common immunologic abnormalities in patients with CMC.
- To evaluate treatment strategies for CMC.
Main Methods:
- Review of existing literature on chronic mucocutaneous candidiasis.
- Analysis of immunologic findings, particularly T lymphocyte cytokine production.
- Assessment of treatment outcomes with antifungal drugs and immunotherapies.
Main Results:
- CMC encompasses a range of persistent fungal infections with potential genetic links.
- A frequent immunological issue involves T lymphocytes failing to produce essential cytokines for cell-mediated immunity against Candida.
- Antifungal medications effectively clear infections.
Conclusions:
- Chronic mucocutaneous candidiasis is a spectrum of disorders.
- Impaired T lymphocyte cytokine production is a key immunologic abnormality.
- Antifungal therapy combined with treatments that restore cellular immunity can lead to long-term remission.
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