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Chronic mucocutaneous candidiasis.

C H Kirkpatrick1

  • 1Department of Medicine, University of Colorado Health Sciences Center, Denver 80206-1210, USA. ckirkpatrick@eri.uchsc.edu

The Pediatric Infectious Disease Journal
|February 27, 2001
PubMed
Summary
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Chronic mucocutaneous candidiasis presents as a spectrum of persistent fungal infections. Genetic factors and impaired T lymphocyte cytokine production contribute, but antifungal drugs and immunotherapy offer effective treatment options.

Area of Science:

  • Immunology
  • Dermatology
  • Infectious Diseases

Background:

  • Chronic mucocutaneous candidiasis (CMC) is a group of disorders characterized by persistent or recurrent Candida infections.
  • These conditions affect the skin, nails, and mucous membranes.
  • Genetic predispositions and immune system defects are implicated in CMC.

Purpose of the Study:

  • To define chronic mucocutaneous candidiasis as a spectrum of disorders.
  • To identify common immunologic abnormalities in patients with CMC.
  • To evaluate treatment strategies for CMC.

Main Methods:

  • Review of existing literature on chronic mucocutaneous candidiasis.
  • Analysis of immunologic findings, particularly T lymphocyte cytokine production.

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  • Assessment of treatment outcomes with antifungal drugs and immunotherapies.

    • Main Results:

    • CMC encompasses a range of persistent fungal infections with potential genetic links.
    • A frequent immunological issue involves T lymphocytes failing to produce essential cytokines for cell-mediated immunity against Candida.
    • Antifungal medications effectively clear infections.

    Conclusions:

    • Chronic mucocutaneous candidiasis is a spectrum of disorders.
    • Impaired T lymphocyte cytokine production is a key immunologic abnormality.
    • Antifungal therapy combined with treatments that restore cellular immunity can lead to long-term remission.