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Comorbidity in generalized anxiety disorder.

R Noyes1

  • 1Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA.

The Psychiatric Clinics of North America
|February 28, 2001
PubMed
Summary

Generalized Anxiety Disorder (GAD) frequently co-occurs with other conditions like major depressive disorder (MDD) and panic disorder. This comorbidity is linked to worse outcomes but may improve with treatment of the primary disorder.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Genetics

Background:

  • Generalized Anxiety Disorder (GAD) exhibits high comorbidity rates, often exceeding those of other anxiety disorders.
  • GAD is a frequent comorbid condition across diverse populations, including children and the elderly.

Purpose of the Study:

  • To examine the prevalence and impact of comorbidity in Generalized Anxiety Disorder (GAD).
  • To understand the relationship between GAD and comorbid conditions, particularly major depressive disorder (MDD) and panic disorder.

Main Methods:

  • Review of existing literature on GAD comorbidity.
  • Analysis of epidemiological and clinical data on co-occurring disorders.

Main Results:

  • GAD commonly co-occurs with depressive disorders (especially MDD) and other anxiety disorders (especially panic disorder).
  • Comorbidity with GAD is associated with increased functional impairment, higher treatment seeking, and poorer outcomes.
  • Twin studies suggest a shared genetic vulnerability between GAD and MDD.

Conclusions:

  • GAD is a significant condition both as a primary disorder and in its comorbid presentations.
  • While comorbid conditions can complicate treatment, addressing the primary disorder may lead to improvements in co-occurring conditions.

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