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[Correction of NO-dependent cardiovascular disorders by adaptation to hypoxia]
S Iu Mashina1, B V Smirin, I Iu Malyshev
1Institute of General Pathology and Pathophysiology, Russian Acad. Med. Sci., Baltiyskaya St., 8, Moscow 125315, Russia.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|March 3, 2001
Abstract:
Spontaneously hypertensive rats (SHR-SP) were adapted to intermittent hypobaric hypoxia in an altitude chamber for 40 days. The adaptation to hypoxia prevented an excessive endothelium-dependent relaxation and hypotension characteristic of myocardial infarction. The adaptation also attenuated the increase in blood pressure and prevented impairment of the endothelium-dependent relaxation in SHR-SP. The universal nature of the adaptation allows to use it for correcting many cardiovascular disorders related to diverse alterations of NO metabolism.