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[Palpable mantel cell lymphoma in the breast]
N Boullanger1, P Renou, J Dugay
1Département de Médecine interne et Onco-hématologie, Centre Hospitalier, F72037 Le Mans.
Presse Medicale (Paris, France : 1983)
|March 7, 2001
Summary
Mantle cell lymphoma (MCL) can present unusually, affecting the breast and eyelid. Early diagnosis via immunohistochemistry and molecular analysis is crucial for this aggressive disease.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Mantle cell lymphoma (MCL) comprises 6% of non-Hodgkin's lymphomas.
- Extranodal involvement is common in MCL.
- Simultaneous breast and eyelid localization is exceptionally rare.
Observation:
- A 71-year-old woman initially suspected of chronic lymphoid leukemia (CLL) presented with fatigue and enlarged lymph nodes.
- Rapidly growing tumors involving both breasts and eyelids were observed.
- Diagnosis was confirmed as MCL through immunoflow cytometry, cytogenetic, and molecular analyses.
Findings:
- MCL can mimic CLL before extranodal involvement.
- MCL with primary breast and eyelid localization indicates aggressive disease.
- Partial remission with polychemotherapy was short-lived (3 months).
Implications:
- Early diagnosis of MCL requires systematic immunohistochemistry and molecular analysis.
- MCL has a poor prognosis with a median survival of 48 months.
- High-dose chemotherapy with stem cell graft should be considered for younger patients.