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Evidence for gliotoxin-glutathione conjugate adducts

P H Bernardo1, C L Chai, G J Deeble

  • 1Department of Chemistry, The Faculties, Australian National University, ACT.

Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
PubMed

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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