Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptoids as endothelin receptor antagonists.

F Dasgupta1, N Gangadhar, M Bruhaspathy

  • 1New Drug Discovery Research, Ranbaxy Laboratories Limited, New Delhi, India. fdcarbo@hotmail.com

Bioorganic & Medicinal Chemistry Letters
|March 7, 2001
PubMed
Summary

New peptoid compounds were synthesized and screened as endothelin receptor antagonists. Several compounds showed potential as lead candidates, exhibiting competitive binding to endothelin receptors (ET(A) and ET(B)) at low micromolar concentrations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of phytochemical traits, proximate composition, and metabolite diversity in Nigella sativa L. genotypes from India.

Scientific reports·2026
Same author

Multi-enzyme producing lignocellulolytic bacteria from biogas slurry: molecular identification and optimization of enzyme production by Bacillus subtilis BCA-1.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]·2026
Same author

Correction: A novel proposed classification system for rock slope stability assessment.

Scientific reports·2026
Same author

Efficacy of aniseed essential oil as natural preservative in meat emulsion at refrigeration temperature.

British poultry science·2026
Same author

Development of a history-taking form for mesothelioma patients at risk of exposure to asbestos.

Public health action·2025
Same author

Drip fertigation improves cumin productivity, essential oil content, water use efficiency and profitability in arid zones of Rajasthan.

Scientific reports·2025

Area of Science:

  • Medicinal Chemistry
  • Pharmacology

Background:

  • Endothelin receptors (ET(A) and ET(B)) play crucial roles in cardiovascular and renal physiology.
  • Developing selective antagonists for these receptors is a therapeutic target.

Purpose of the Study:

  • To synthesize novel peptoid-based compounds.
  • To evaluate their potential as endothelin receptor antagonists.

Main Methods:

  • Synthesis of a new series of peptoid compounds.
  • Competitive binding assays using (125I) endothelin to assess receptor affinity.
  • Determination of IC50 values for antagonist potency.

Main Results:

  • Successful synthesis of novel peptoid derivatives.
  • Identification of compounds with competitive binding affinity for endothelin receptors.

Related Experiment Videos

  • Discovery of lead compounds with IC50 values in the low micromolar range.

    • Conclusions:

    • The synthesized peptoids demonstrate potential as endothelin receptor antagonists.
    • Further optimization of these compounds may lead to novel therapeutic agents.