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Regulation of laminin and COUP-TF expression in extraembryonic endodermal cells
1Department of Human Anatomy and Cell Biology, University of Liverpool, Ashton Street, L69 3GE, Liverpool, UK.
Mechanisms of Development
|March 7, 2001
Abstract:
Laminin expression and the subsequent deposition of a basement membrane by primitive endoderm cells is necessary for early mammalian development. We demonstrate that the transcription factors COUP-TF I and II are up-regulated in primitive endoderm cells faster than LAMB1 and LAMC1, and that either COUP-TF is sufficient to induce expression of these laminin genes.