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Updated: Oct 9, 2026

Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
Published on: January 17, 2016
Expression pattern of the drm/gremlin gene during chicken embryonic development
B Bardot1, L Lecoin, E Huillard
1Régulations Cellulaires et Oncogénèse, UMR 146 du CNRS, Institut Curie, Centre Universitaire, 91405 Orsay, Cedex, France.
Abstract:
The drm gene encodes a cystine knot-containing secreted and cell membrane-associated glycoprotein shown to be an antagonist of BMPs. Drm was recently reported to play a crucial role in limb bud development, by its capacity to bind BMPs. Here, we have studied the expression pattern of drm transcripts during chicken development, by using whole-mount in situ hybridization. We show that, from stage 22HH to stage 26HH, in addition to limb buds, drm is expressed in cephalic neural crest-derived branchial arches I, II and III, in the medio-dorsal lip of the myotome and in the superficial dermatome
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