Related Experiment Videos
Extraskeletal Ewing's sarcoma of the nose.
A Böör1, I Jurkovic, I Friedmann
1Institute of Pathology, Medical Faculty, P. J. Safárik's University, Kosice, Slovak Republic.
The Journal of Laryngology and Otology
|March 10, 2001
Summary
A rare nasal tumor, extraskeletal Ewing's sarcoma (EWS/PNET), was identified in a young woman. Surgical excision and adjuvant therapies significantly improved her prognosis.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Extraskeletal Ewing's sarcoma (EWS/PNET) is a rare malignant neoplasm.
- Nasal obstruction and epistaxis can be presenting symptoms.
Observation:
- A 20-year-old woman presented with nasal obstruction and epistaxis.
- Microscopy revealed a neoplasm of undifferentiated cells with clear, vacuolated cytoplasm rich in glycogen.
- Immunohistochemistry showed expression of the MIC2 gene (CD99 marker).
Findings:
- Electron microscopy confirmed simple cells with abundant glycogen and few mitochondria.
- The tumor cells expressed CD99, a marker characteristic of EWS/PNET.
- Tumor cells were confined to the nasal mucosa without bone invasion.
Implications:
- Early diagnosis and multimodal treatment (surgery, chemotherapy, radiotherapy) improve EWS/PNET prognosis.
- This case highlights the importance of considering EWS/PNET in nasal neoplasms.
- Understanding the cellular characteristics aids in accurate diagnosis and treatment planning.