Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Immunomodulation by macrolide antibiotics.

M T Labro¹, H Abdelghaffar

¹INSERM U479, CHU Xavier Bichat, Paris, France. labro@bichat.inserm.fr

Journal of Chemotherapy (Florence, Italy)

|March 10, 2001

Summary

Macrolide antibiotics concentrate in host cells, impacting immune responses and cell metabolism. Erythromycin A derivatives show anti-inflammatory effects, potentially by down-regulating inflammatory cytokine production.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of CD209L tandem repeats polymorphism with susceptibility to human immunodeficiency virus-1 infection, disease progression, and treatment outcomes: a Moroccan cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2015

Same author

[Neuropsychiatric side effects of antituberculosis agents].

Revue medicale de Liege·2011

Same author

[Rare primary chest wall sarcoma: the synovialosarcoma].

Revue des maladies respiratoires·2011

Same author

[Hypersensitivity reactions to antituberculous therapy].

Revue des maladies respiratoires·2010

Same author

[Effect of tobacco smoking on pulmonary tuberculosis].

Revue medicale de Liege·2010

Same author

Multiple myeloma presenting with multiple thoracic manifestations.

The Indian journal of chest diseases & allied sciences·2010

Area of Science:

Pharmacology
Immunology
Cell Biology

Background:

Macrolide antibiotics accumulate within host cells, influencing cellular metabolism and function.
Extensive research exists on macrolide-induced modulation of immune responses.
Erythromycin A derivatives exhibit anti-inflammatory properties in various settings.

Purpose of the Study:

To explore the mechanisms behind macrolide-induced immunomodulation.
To investigate potential targets of macrolide antibiotics beyond direct antimicrobial action.
To examine the link between macrolide transport systems and drug resistance/disease.

Main Methods:

In vitro studies on inflammatory cytokine and oxidant production by phagocytes.
In vivo animal models assessing anti-inflammatory activity.
Clinical observations in conditions like diffuse panbronchiolitis (DPB).

Main Results:

Macrolides down-regulate inflammatory cytokine and oxidant production by phagocytes.
Erythromycin A derivatives demonstrate anti-inflammatory activity.
Potential targets include bacterial virulence factors and host cells.

Conclusions:

Macrolides possess immunomodulatory and anti-inflammatory properties.
Mechanisms involve down-regulation of phagocyte inflammatory mediators.
Macrolide transport systems may interact with P-glycoprotein, impacting drug resistance and cystic fibrosis.

Related Experiment Videos