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[E-cadherin expression and its clinical significance in cervical cancer]
1Department of Oncology, First Affiliated Hospital, Xi'an University of Medical Sciences, Xi'an 710061, China.
Objective:
To study the clinical significance of E-cadherin (E-CD) expression in cervical cancer.
Methods:
Specimens of 60 cervical cancer, 10 normal cervical epithelia and 12 cervical intraepithelial neoplasia(CIN) were examined for E-CD expression by immunohistochemical staining.
Results:
E-CD was expressed in all of 10 specimens of normal cervical epithelia. Positive staining was seen in 66.7% of CIN, 46.7% of cervical cancer. In cervical cancer, the frequency of abnormal E-CD expression was correlated to pathologic grade, lymph node metastasis and clinical stage (P < 0.05). The higher the pathologic grade of tumor, the lower was the expression of E-CD. Negative E-CD expression was significantly more frequent in the advanced stage of cervical cancer with lymph node metastasis.
Conclusion:
Decreased expression of E-CD is a useful parameter of cervical malignancy.
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