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Related Experiment Videos

Conditioned suppression of behavior maintained by intracranial stimulation as a function of stimulation intensity.

P J Russell

    Journal of the Experimental Analysis of Behavior
    |March 1, 1975
    PubMed
    Summary

    Rats showed less conditioned suppression when receiving high-intensity brain stimulation, even with foot shock. This suggests stimulation intensity, not just shock, impacts suppression, offering insights into motivation.

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    Area of Science:

    • Neuroscience
    • Behavioral Psychology
    • Animal Models

    Background:

    • Conditioned suppression is a behavioral phenomenon where an animal reduces responding for a reward when a warning signal predicts an aversive stimulus.
    • Intracranial stimulation (ICS) of the lateral hypothalamus is a potent reward, and its associated behaviors have been studied for resistance to suppression.

    Purpose of the Study:

    • To investigate the role of intracranial stimulation (ICS) intensity in conditioned suppression.
    • To determine if the intensity of brain stimulation affects the degree of behavioral suppression when paired with an aversive stimulus.

    Main Methods:

    • Two experiments were conducted using rats trained to lever press for lateral hypothalamic ICS on a fixed-ratio 1 schedule.
    • Experiment I paired a moderate foot shock with a warning stimulus to elicit conditioned suppression of lever pressing for low-intensity ICS.

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  • Experiment II alternated low and high intensities of ICS within the same session, assessing suppression under both conditions with paired foot shock.

    • Main Results:

    • Conditioned suppression of lever pressing for ICS was observed with low-intensity stimulation when paired with foot shock.
    • Suppression was minimal or absent when high-intensity ICS was used, despite the same foot shock and warning stimulus pairing.
    • The degree of conditioned suppression was inversely related to the intensity of the ICS, independent of response rates.

    Conclusions:

    • The intensity of lateral hypothalamic intracranial stimulation significantly influences conditioned suppression.
    • High-intensity ICS appears to be more resistant to suppression, explaining previous reports of such resistance.
    • Findings support a motivational analysis of conditioned suppression, where reward intensity modulates the impact of aversive stimuli.