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A molecular clock involved in somite segmentation.

M Maroto1, O Pourquié

  • 1Laboratoire de Génétique et de Physiologie du Développement (LGPD), Developmental Biology Institute of Marseille (IBDM), CNRS-INSERM-Université de la Méditerranée-AP de Marseille, France.

Current Topics in Developmental Biology
|March 10, 2001
PubMed
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Somite formation relies on a molecular clock controlling gene expression, like c-hairy1 and lunatic fringe, within the presomitic mesoderm. This process is crucial for establishing the segmented body plan during embryonic development.

Area of Science:

  • Developmental biology
  • Molecular embryology
  • Genetics

Background:

  • Somites are transient embryonic structures crucial for metameric pattern formation.
  • Somitogenesis involves sequential processes including pattern generation, anteroposterior identity specification, and border formation.

Purpose of the Study:

  • To explore the role of the molecular clock and Notch signaling pathway in somitogenesis.
  • To review genes involved in the molecular events of somite formation.

Main Methods:

  • Analysis of rhythmic gene expression patterns in the presomitic mesoderm (PSM).
  • Investigating the link between oscillating gene expression (c-hairy1, lunatic fringe) and Notch signaling.
  • Reviewing existing literature on genes involved in somitogenesis.

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Main Results:

  • Rhythmic expression of c-hairy1 and lunatic fringe in the PSM suggests a molecular oscillator.
  • Oscillating gene expression patterns indicate a role in temporal control of Notch pathway activation.
  • This temporal control is essential for the regular segmentation of somites.

Conclusions:

  • The molecular clock, through rhythmic gene expression, plays a critical role in temporal regulation during somitogenesis.
  • The Notch signaling pathway is intricately linked with the molecular clock in orchestrating somite formation.
  • Understanding these molecular mechanisms provides insight into embryonic patterning and segmentation.