Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis of thyroid nodules: histological classification?

G B Salabè1

  • 1CNR Institute of Neurobiology and Molecular Medicine, Rome, Italy. Giovanni.Battista.Salabe@ims.rm.cnr.it

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 10, 2001
PubMed
Summary

Thyroid nodules arise from genetic and epigenetic factors, manifesting as hyperplastic, neoplastic, colloid, cystic, or thyroiditic types. Understanding these distinct histological features is key to comprehending thyroid nodule development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Reproductive history, contraceptives and cigarette smoke as risk factors for cancer of the thyroid in women. Case-control study].

Minerva endocrinologica·2001
Same author

Lipoprotein(a) increase associated with thyroid autoimmunity.

European journal of endocrinology·1997
Same author

[Thyroid carcinoma. Retrospective analysis of case records of the III. Surgery Department at the Umberto I Clinics in Rome in the years 1990-93].

Minerva endocrinologica·1996
Same author

Thyroglobulin determined in thyroid fine needle aspiration biopsies by radial immunodiffusion and electroimmunodiffusion.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies·1996
Same author

Aetiology of thyroid cancer: an epidemiological overview.

Thyroidology·1994
Same author

[Efficacy of L-thyroxine (L-T4) therapy on the volume of the thyroid gland and nodules in patients with euthyroid nodular goiter (ENG)].

Minerva medica·1992

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Thyroid nodule genesis involves amplified thyroid heterogeneity through genetic and/or epigenetic mechanisms.
  • Five distinct histological types of thyroid nodules are identified: hyperplastic, neoplastic, colloid, cystic, and thyroiditic.

Purpose of the Study:

  • To classify thyroid nodules based on distinct histological features.
  • To elucidate the underlying genetic and molecular mechanisms driving the development of different thyroid nodule types.

Main Methods:

  • Histological classification of thyroid nodules into five categories.
  • Review of genetic mutations and molecular pathways implicated in thyroid carcinogenesis and hyperplasia.
  • Analysis of pathological features associated with colloid, cystic, and thyroiditic nodules.

Related Experiment Videos

Main Results:

  • Hyperplastic nodules involve TSHR, cAMP, and PKA pathways, with constitutive cAMP overproduction linked to TSHR or Gs protein mutations.
  • Neoplastic nodules are associated with oncogenes like mutated TSHR, gsp, TRK, RET/PTC, ras, and c-MET; p53 mutations contribute to cancer progression.
  • Colloid nodules may result from defective thyroglobulin reabsorption or compaction, while cystic nodules often arise from pseudocysts due to necrosis or VEGF/VPF.
  • Thyroiditic nodules encompass lymphocytic thyroiditis, potentially associated with papillary thyroid carcinoma or lymphoma.

Conclusions:

  • Thyroid nodule development is a complex process influenced by various genetic and molecular factors.
  • Distinct histological subtypes reflect different pathogenetic mechanisms, ranging from hormonal dysregulation to oncogenic activation and inflammatory processes.