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Lipoprotein(a) increase associated with thyroid autoimmunity

H Lotz1, G B Salabè

  • 1Istituto di Medicina Sperimentale, Consiglio Nazionale delle Ricerche, Roma, Italy.

European Journal of Endocrinology
|January 1, 1997
PubMed
Summary

Thyroid autoimmunity is linked to higher lipoprotein(a) (Lp(a)) levels in men and postmenopausal women, but not premenopausal women, suggesting estrogen may play a protective role. This association persists even in euthyroid individuals with autoimmune thyroid disease.

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Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Research
  • Immunology

Background:

  • Conflicting data exists on serum lipoprotein(a) (Lp(a)) levels in hypothyroidism.
  • The relationship between thyroid autoimmunity and Lp(a) independent of thyroid status requires clarification.
  • Understanding this link is crucial for cardiovascular risk assessment in autoimmune thyroid conditions.

Purpose of the Study:

  • To investigate the association between thyroid autoimmunity and serum Lp(a) concentrations.
  • To determine if this association is independent of thyroid hormone status.
  • To explore potential gender-specific differences, including the influence of estrogen.

Main Methods:

  • Serum Lp(a) levels were measured using ELISA in individuals with and without thyroid antibodies (T-Abs).

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  • Study groups included males, premenopausal females, and postmenopausal females, all normolipidemic.
  • Comparisons were made between T-Abs positive and negative subjects, matched for age.

    • Main Results:

    • Significantly elevated Lp(a) levels were observed in T-Abs positive males compared to controls.
    • No significant difference in Lp(a) was found in premenopausal females, suggesting a potential estrogen effect.
    • Postmenopausal females with T-Abs showed significantly increased Lp(a) levels, as did euthyroid hypothyroid patients on L-thyroxine.

    Conclusions:

    • Thyroid autoimmunity is associated with increased serum Lp(a) levels in males and postmenopausal females, irrespective of thyroid status.
    • Estrogen may mitigate the Lp(a) elevation associated with thyroid autoimmunity in premenopausal women.
    • These findings highlight a potential link between autoimmune thyroid disease and cardiovascular risk markers.