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Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvum
1Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, NeuroImmunology Lab D-305, 914 South 8th St., Minneapolis, MN 55404, USA. wsheng@biosci.cbs.umn.edu
Clinical and Diagnostic Laboratory Immunology
|March 10, 2001
Abstract:
Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.