Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfaction in Drosophila: coding, genetics and e-genetics.

C Warr1, P Clyne, M de Bruyne

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.

Chemical Senses
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells.

The Journal of experimental medicine·1998
Same author

Ca2+-channel-dependent and -independent inhibition of exocytosis by extracellular ATP in voltage-clamped rat adrenal chromaffin cells.

Pflugers Archiv : European journal of physiology·1998
Same author

Protein disulfide isomerase as a regulator of chloroplast translational activation.

Science (New York, N.Y.)·1998
Same author

Amplification and sequencing of end fragments from bacterial artificial chromosome clones by single-primer polymerase chain reaction.

Analytical biochemistry·1997
Same author

Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital-responsive unit in native chromatin.

The Journal of biological chemistry·1997
Same author

Brucella abortus arginase and ornithine cyclodeaminase genes are similar to Ti plasmid arginase and ornithine cyclodeaminase.

Biochimica et biophysica acta·1997
Same journal

A method for assessing approach and avoidance behavior across multiple olfactory stimuli in mice including multivariate hypothesis comparisons.

Chemical senses·2026
Same journal

From Receptors to Behavior: Molecular and Functional Logic of Sensory Coding in the Mouse Accessory Olfactory System.

Chemical senses·2026
Same journal

Vomeronasal sensory input and its social behavioral output.

Chemical senses·2026
Same journal

Reference data for Bayesian adaptive QUEST-based taste recognitions thresholds from pooled individual participant data.

Chemical senses·2026
Same journal

Expression of Calca gene-derived peptides in the murine taste system.

Chemical senses·2026
Same journal

The trigeminal function questionnaire (TriFunQ): a tool for clinical and research use.

Chemical senses·2026
See all related articles

Researchers explored how fruit flies (Drosophila) detect odors by analyzing olfactory receptor neurons (ORNs). They identified a large family of odor receptor genes and a key gene, acj6, crucial for ORN function.

Area of Science:

  • Neuroscience
  • Genetics
  • Olfactory system research

Background:

  • Odor coding in Drosophila is complex, involving distinct classes of olfactory receptor neurons (ORNs).
  • Each ORN class has a specific odor response spectrum, and their organization in sensilla follows a strict pairing rule.

Purpose of the Study:

  • To identify odor receptor genes responsible for the specific odor responses of ORN classes.
  • To understand the molecular mechanisms underlying odor receptor gene expression in ORNs.

Main Methods:

  • Single-unit electrophysiology was used for functional analysis of individual ORNs.
  • A novel algorithm was developed to search DNA databases for structurally similar proteins to identify potential odor receptors.
  • Genetic screening identified the acj6 gene involved in olfactory behavior.

Related Experiment Videos

Main Results:

  • Six distinct classes of ORNs were identified in the maxillary palp, organized by a strict pairing rule.
  • A large family of candidate odor receptor genes was discovered using a structure-based search algorithm.
  • The acj6 gene was identified as a transcription factor regulating a subset of these odor receptor genes.

Conclusions:

  • The study reveals a significant family of odor receptor genes in Drosophila.
  • The acj6 gene plays a critical role in the regulation of odor receptor gene expression in ORNs.
  • This research provides insights into the cellular and molecular basis of odor coding in flies.