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Robertson's Mutator transposons in A. thaliana are regulated by the chromatin-remodeling gene Decrease in DNA

T Singer¹, C Yordan, R A Martienssen

¹Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Genes & Development

|March 10, 2001

Summary

Plant DNA transposons, like Mutator elements, are regulated by DNA methylation and chromatin remodeling. The Decrease in DNA Methylation (DDM1) mutant activates these elements, impacting gene silencing and plant phenotypes.

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Area of Science:

Plant molecular biology
Epigenetics
Genomics

Background:

Robertson's Mutator transposable elements in maize show cycles of activity linked to cytosine methylation changes.
Mutator-like elements in Arabidopsis are heavily methylated and inactive.

Purpose of the Study:

To investigate the role of chromatin remodeling in the regulation of plant DNA transposons.
To understand the function of the Decrease in DNA Methylation (DDM1) mutant in transposon activity and epigenetic phenomena.

Main Methods:

Analysis of Arabidopsis thaliana genome.
Characterization of the ddm1 mutant.
Assessing DNA methylation and transposon activity.

Main Results:

Related Experiment Videos

The ddm1 mutant causes demethylation and activation of previously inactive Mutator-like elements.

DDM1's chromatin remodeling activity leads to loss of heterochromatic DNA methylation.

Transposition in ddm1 strains may contribute to unlinked mutant phenotypes.

Conclusions:

DNA transposon regulation in plants is linked to chromatin remodeling.
DDM1 plays a crucial role in epigenetic silencing, gene silencing, and paramutation, in addition to transposon regulation.