Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ACE gene polymorphism and long-term renal graft function.

O Viklický1, J A Hubácek, J Pitha

  • 1Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Vídenská 1958/9, 14021 4, Prague, Czech Republic. ondrej.viklicky@medicon.cz

Clinical Biochemistry
|March 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiovascular Effects of Early and Postponed Statin Treatment After Ovariectomy in Prediabetic Rat.

Physiological research·2026
Same author

Soluble endoglin reflects endothelial dysfunction in myocardial infarction patients: a retrospective observational study.

International journal of medical sciences·2025
Same author

PNPLA3 I148M variant is the main driver of weight gain after hepatitis C cure.

Scientific reports·2025
Same author

The Impact of COVID-19 Third Dose Vaccination on the Magnitude of Antigen Specific T Cells in Kidney Transplant Patients.

Physiological research·2024
Same author

Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers.

Cytokine·2024
Same author

ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population.

Physiological research·2023
Same journal

Extremely high follicle-stimulating hormone with normal ovarian function.

Clinical biochemistry·2026
Same journal

Analytical outlier rates for Roche fifth generation cardiac troponin T stat using biotin sensitive and insensitive reagent lots.

Clinical biochemistry·2026
Same journal

Evaluation of hemoglobin interference thresholds for chemical urinalysis panels.

Clinical biochemistry·2026
Same journal

Integrated genomic and biochemical diagnosis of a novel homozygous start-loss variant in AKR1D1 associated with neonatal cholestasis.

Clinical biochemistry·2026
Same journal

Agreement between POC glucose meters and blood gas analyzers varies across ICU patient populations.

Clinical biochemistry·2026
Same journal

From variability to value: Advancing vancomycin therapeutic drug monitoring toward decision-grade practice through commutability-informed external quality assessment and uncertainty-aware reporting.

Clinical biochemistry·2026
See all related articles

The DD variant of the angiotensin-converting enzyme (ACE) I/D gene polymorphism is linked to superior long-term kidney graft function. This finding may improve outcomes for renal transplant recipients.

Area of Science:

  • Nephrology
  • Genetics
  • Transplantation immunology

Background:

  • Long-term survival of kidney transplants remains suboptimal, with few grafts functioning beyond 15 years.
  • The role of genetic factors in influencing renal transplant outcomes requires further investigation.

Purpose of the Study:

  • To investigate the association between angiotensin-converting enzyme (ACE) gene polymorphism and long-term graft function after renal transplantation.
  • To identify genetic markers that may predict successful long-term outcomes in kidney transplant recipients.

Main Methods:

  • Polymerase chain reaction (PCR) was used to analyze the ACE I/D gene polymorphism.
  • Genotyping was performed in patients with long-term graft function (LTF > 15 years) and compared to control groups of transplant recipients and a general population sample.

Related Experiment Videos

Main Results:

  • A significant difference in genotype distribution was observed between the LTF group and transplant control groups (p < 0.05).
  • DD homozygotes in the LTF group exhibited significantly better creatinine clearance compared to ID and II genotypes (p < 0.05).
  • No significant differences in genotype distribution were found between transplant recipients and the general population sample.

Conclusions:

  • The DD variant of the ACE I/D gene polymorphism is associated with excellent long-term kidney graft function.
  • ACE gene polymorphism may serve as a potential predictive marker for successful renal allograft survival.