Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Statins and unstable angina: MIRACL].

J Puel1

  • 1Service de Cardiologie B, CHU Rangueil, 1, avenue Jean Pouilhès, 31403 Toulouse Cedex. puel.jacques@chu-toulouse.fr

Annales D'Endocrinologie
|March 10, 2001
PubMed
Summary

High-dose Atorvastatin effectively reduces ischemic events in acute unstable angina and non-Q-wave myocardial infarction. This highlights statins as a crucial addition to treating acute coronary syndromes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plaque rupture and morphological characteristics of the culprit lesion in acute coronary syndromes without significant angiographic lesion: analysis by intravascular ultrasound.

Annales de cardiologie et d'angeiologie·2011
Same author

[Psychological factors and quality of life after percutaneous transluminal coronary angioplasty].

L'Encephale·2009
Same author

Long-term clinical outcome after percutaneous coronary interventions in the elderly: results for 512 consecutive patients.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2009
Same author

Predictors of infarct artery patency after prehospital thrombolysis: the multicentre, prospective, observational OPTIMAL study.

Heart (British Cardiac Society)·2008
Same author

Clinical and angiographic results of angioplasty with a paclitaxel-eluting stent for unprotected left main coronary artery disease (a study of 101 consecutive patients).

Archives of cardiovascular diseases·2008
Same author

Differential display fingerprints: new approach to characterize smooth muscle cells and human coronary atherectomy tissues.

Pathologie-biologie·2007

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Statins are established for lowering hypercholesterolemia and preventing cardiovascular events.
  • Their role in acute coronary syndromes, specifically unstable angina, was explored.

Purpose of the Study:

  • To evaluate the efficacy of high-dose Atorvastatin in managing acute unstable angina and non-Q-wave myocardial infarction.
  • To assess the impact of statin therapy on ischemic events in this patient population.

Main Methods:

  • A comparative study involving high-dose Atorvastatin (80 mg/day) administration during the acute phase.
  • Analysis of ischemic events, risk stratification using electric and biologic markers, and comparison with invasive strategies.

Main Results:

  • High-dose Atorvastatin significantly reduced ischemic events (RR=0.84, p=0.048) when added to anticoagulants and antiplatelet agents.
  • Risk stratification using electrocardiographic and biomarker data is crucial for guiding treatment decisions.

Conclusions:

  • High-dose Atorvastatin is a valuable therapeutic agent for acute coronary syndromes, particularly unstable angina.
  • Treatment decisions for acute coronary syndromes should integrate medical management with risk stratification based on clinical, electric, and biologic factors.

Related Experiment Videos