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IgE regulation and roles in asthma pathogenesis.
1Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA, USA.
The Journal of Allergy and Clinical Immunology
|March 10, 2001
Summary
Immunoglobulin E (IgE) is linked to inherited asthma and its severity. Understanding IgE
Area of Science:
- Immunology
- Allergy
- Pulmonology
Background:
- Asthma and the tendency to produce immunoglobulin E (IgE) are inherited as linked traits.
- In asthma patients, IgE levels correlate with disease severity and bronchial hyperresponsiveness.
- The critical role of IgE in asthma pathogenesis has led to the development of IgE blockers.
Purpose of the Study:
- To review the mechanisms by which IgE contributes to immediate hypersensitivity and chronic allergic inflammation in the airways.
- To discuss molecular genetic events in IgE production by B cells.
- To examine cellular and cytokine factors supporting IgE production in the bronchial mucosal microenvironment.
Main Methods:
- Literature review focusing on IgE's role in asthma.
- Discussion of molecular genetics of IgE production.
- Analysis of cellular and cytokine involvement in the bronchial mucosa.
Main Results:
- IgE participates in immediate hypersensitivity and chronic allergic bronchial inflammation.
- Molecular genetic events and microenvironmental factors influence IgE production.
- Significant knowledge gaps remain regarding IgE's role and its production influences.
Conclusions:
- IgE plays a dual role in asthma, mediating immediate responses and chronic inflammation.
- Further research is needed to fully understand IgE's contribution to asthma.
- Clinical experience with anti-IgE therapies will clarify IgE's mechanisms and therapeutic potential.
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