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A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
Localization of androgen receptor expression in human bone marrow
A Mantalaris1, N Panoskaltsis, Y Sakai
1Department of Chemical Engineering, University of Rochester, Rochester, NY 14627-0166, USA.
The Journal of Pathology
|March 10, 2001
Summary
Androgen receptors (AR) are widely present in bone marrow cells, including stromal cells and immune cells. This suggests androgens directly influence various bone marrow cell types.
Area of Science:
- Hematology
- Immunology
- Cell Biology
Background:
- Androgens influence hematopoietic and immune systems.
- Androgens stimulate hematopoiesis in bone marrow failure.
- Identifying androgen targets in bone marrow is crucial.
Purpose of the Study:
- To identify bone marrow cell types targeted by androgens.
- To investigate androgen receptor (AR) expression in human bone marrow.
Main Methods:
- Used an androgen receptor (AR)-specific antibody.
- Localized AR expression in normal human bone marrow biopsies.
- Examined AR expression across different cell types and age groups.
Main Results:
- AR was ubiquitously expressed in bone marrow of both sexes, irrespective of age.
- AR was found in stromal cells, macrophages, endothelial cells, myeloblasts, myelocytes, neutrophils, and megakaryocytes.
- AR was not detected in lymphoid cells, erythroid cells, or eosinophils.
Conclusions:
- Androgens likely exert direct effects on a broad range of bone marrow cells via AR.
- Findings provide insights into androgen's role in hematopoiesis and immunity.
- Identified specific bone marrow cell populations as direct targets of androgen action.
